Serine/arginine-rich splicing factor 12 (SRSF12)
Homo sapiens — UniProt Q8WXF0
Data last refreshed: (UniProt release unknown)
Key facts
Serine/arginine-rich splicing factor 12 (SRSF12) is a protein from Homo sapiens identified by UniProt accession Q8WXF0, 261 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q8WXF0; gene symbol SRSF12.
- Organism: Homo sapiens.
- Length: 261 amino acids.
- Top disease associations (Open Targets): body height, sleep duration and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/arginine-rich splicing factor 12 |
|---|---|
| UniProt accession | Q8WXF0 |
| Gene | SRSF12 |
| Organism | Homo sapiens |
| Length | 261 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- body height · score 0.37
- sleep duration · score 0.34
- serum metabolite measurement · score 0.17
- neutrophil percentage of leukocytes · score 0.11
- monocyte count · score 0.11
- lean body mass · score 0.08
- mental or behavioural disorder · score 0.06
- monocyte percentage of leukocytes · score 0.04
- hepatocellular carcinoma · score 0.04
- pancreatic adenocarcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXF0-F1 | alphafold | PREDICTED | 62.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXF0.
Amino-acid sequence (261 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SRSF12?
The strongest Open Targets associations for SRSF12 are body height, sleep duration, serum metabolite measurement, neutrophil percentage of leukocytes and monocyte count.
How long is the SRSF12 protein?
The Homo sapiens SRSF12 protein (UniProt Q8WXF0) is 261 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXF0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXF0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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