Relaxin-3 (RLN3)
Homo sapiens — UniProt Q8WXF3
Data last refreshed: (UniProt release unknown)
Key facts
Relaxin-3 (RLN3) is a protein from Homo sapiens identified by UniProt accession Q8WXF3, 142 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q8WXF3; gene symbol RLN3.
- Organism: Homo sapiens.
- Length: 142 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, squamous cell lung carcinoma and gastric adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Relaxin-3 |
|---|---|
| UniProt accession | Q8WXF3 |
| Gene | RLN3 |
| Organism | Homo sapiens |
| Length | 142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.18
- squamous cell lung carcinoma · score 0.12
- gastric adenocarcinoma · score 0.12
- hemoglobin D disease · score 0.04
- microcytic anemia with liver iron overload · score 0.04
- severe congenital hypochromic anemia with ringed sideroblasts · score 0.04
- Adult-onset autosomal recessive sideroblastic anemia · score 0.04
- hemochromatosis type 5 · score 0.04
- FTH1-related iron overload · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXF3-F1 | alphafold | PREDICTED | 62.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXF3.
Amino-acid sequence (142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RLN3?
The strongest Open Targets associations for RLN3 are cutaneous melanoma, squamous cell lung carcinoma, gastric adenocarcinoma, hemoglobin D disease and microcytic anemia with liver iron overload.
How long is the RLN3 protein?
The Homo sapiens RLN3 protein (UniProt Q8WXF3) is 142 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXF3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXF3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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