Gamma-crystallin N (CRYGN)

About Gamma-crystallin N

Gamma-crystallin N (CRYGN) is a protein from Homo sapiens identified by UniProt accession Q8WXF5, 182 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Gamma-crystallin N
UniProt accession	Q8WXF5
Gene	CRYGN
Organism	Homo sapiens
Length	182 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

Abnormality of refraction · score 0.11
heel bone mineral density · score 0.08
46,XY complete gonadal dysgenesis · score 0.05
cryptorchidism · score 0.05
Testicular regression syndrome · score 0.05
familial male-limited precocious puberty · score 0.05
46,XX testicular disorder of sex development · score 0.04
46,XY disorder of sex development due to isolated 17,20 lyase deficiency · score 0.04
partial chromosome Y deletion · score 0.04
46,XX ovotesticular disorder of sex development · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WXF5-F1	alphafold	PREDICTED	77.56	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXF5.

Amino-acid sequence (182 residues)

MAQRSGKITL YEGKHFTGQK LEVFGDCDNF QDRGFMNRVN SIHVESGAWV CFNHPDFRGQ QFILEHGDYP DFFRWNSHSD HMGSCRPVGM HGEHFRLEIF EGCNFTGQCL EFLEDSPFLQ SRGWVKNCVN TIKVYGDGAA WSPRSFGAED FQLSSSLQSD QGPEEATTKP ATTQPPFLTA NL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards