About Atlastin-1
Atlastin-1 (ATL1) is a protein
from Homo sapiens identified by UniProt accession
Q8WXF7, 558 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (104)
Diseases linked to this target (Open Targets).
- hereditary spastic paraplegia 3A · score 0.81
- Autosomal dominant spastic paraplegia type 3 · score 0.81
- hereditary spastic paraplegia · score 0.64
- hereditary sensory and autonomic neuropathy type 1 · score 0.64
- Spastic paraplegia · score 0.40
- genetic disorder · score 0.40
- bone density · score 0.38
- urate measurement · score 0.38
- hereditary sensory and autonomic neuropathy · score 0.37
- Distal sensory impairment · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q8WXF7.
Amino-acid sequence (558 residues)
MAKNRRDRNS WGGFSEKTYE WSSEEEEPVK KAGPVQVLIV KDDHSFELDE TALNRILLSE AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV GDYNEPLTGF SWRGGSERET TGIQIWSEIF LINKPDGKKV AVLLMDTQGT FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ NVQEDDLQHL QLFTEYGRLA MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL KVSGNQHEEL QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL IPWLLSPESL DIKEINGNKI TCRGLVEYFK AYIKIYQGEE LPHPKSMLQA TAEANNLAAV ATAKDTYNKK MEEICGGDKP FLAPNDLQTK HLQLKEESVK LFRGVKKMGG EEFSRRYLQQ LESEIDELYI QYIKHNDSKN IFHAARTPAT LFVVIFITYV IAGVTGFIGL DIIASLCNMI MGLTLITLCT WAYIRYSGEY RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLYHQ AFPTPKSEST EQSEKKKM
Explore Atlastin-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets