DNA-binding death effector domain-containing protein 2 (DEDD2)
Homo sapiens — UniProt Q8WXF8
Data last refreshed: (UniProt release unknown)
Key facts
DNA-binding death effector domain-containing protein 2 (DEDD2) is a protein from Homo sapiens identified by UniProt accession Q8WXF8, 326 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q8WXF8; gene symbol DEDD2.
- Organism: Homo sapiens.
- Length: 326 amino acids.
- Top disease associations (Open Targets): eosinophil count, breast adenocarcinoma and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-binding death effector domain-containing protein 2 |
|---|---|
| UniProt accession | Q8WXF8 |
| Gene | DEDD2 |
| Organism | Homo sapiens |
| Length | 326 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.21
- breast adenocarcinoma · score 0.18
- forced expiratory volume · score 0.14
- vital capacity · score 0.11
- head and neck squamous cell carcinoma · score 0.10
- chronotype measurement · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
- sitting height measurement · score 0.06
- lymphocyte count · score 0.05
- monocyte count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXF8-F1 | alphafold | PREDICTED | 72.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXF8.
Amino-acid sequence (326 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEDD2?
The strongest Open Targets associations for DEDD2 are eosinophil count, breast adenocarcinoma, forced expiratory volume, vital capacity and head and neck squamous cell carcinoma.
How long is the DEDD2 protein?
The Homo sapiens DEDD2 protein (UniProt Q8WXF8) is 326 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXF8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXF8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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