Suppressor of cytokine signaling 4 (SOCS4)
Homo sapiens — UniProt Q8WXH5
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 4 (SOCS4) is a protein from Homo sapiens identified by UniProt accession Q8WXH5, 440 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q8WXH5; gene symbol SOCS4.
- Organism: Homo sapiens.
- Length: 440 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, urate measurement and chronotype measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 4 |
|---|---|
| UniProt accession | Q8WXH5 |
| Gene | SOCS4 |
| Organism | Homo sapiens |
| Length | 440 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- urate measurement · score 0.14
- chronotype measurement · score 0.08
- common variable immunodeficiency · score 0.06
- Knee pain · score 0.05
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.05
- immunodeficiency 18 · score 0.05
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05
- self reported educational attainment · score 0.05
- intelligence · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXH5-F1 | alphafold | PREDICTED | 65.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXH5.
Amino-acid sequence (440 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS4?
The strongest Open Targets associations for SOCS4 are neurodegenerative disease, urate measurement, chronotype measurement, common variable immunodeficiency and Knee pain.
How long is the SOCS4 protein?
The Homo sapiens SOCS4 protein (UniProt Q8WXH5) is 440 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXH5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXH5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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