Ras-related protein Rab-40A (RAB40A)
Homo sapiens — UniProt Q8WXH6
Data last refreshed: (UniProt release unknown)
Key facts
Ras-related protein Rab-40A (RAB40A) is a protein from Homo sapiens identified by UniProt accession Q8WXH6, 277 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q8WXH6; gene symbol RAB40A.
- Organism: Homo sapiens.
- Length: 277 amino acids.
- Top disease associations (Open Targets): vaginal discharge, Blackfan-Diamond anemia and hereditary persistence of fetal hemoglobin-sickle cell disease syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ras-related protein Rab-40A |
|---|---|
| UniProt accession | Q8WXH6 |
| Gene | RAB40A |
| Organism | Homo sapiens |
| Length | 277 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- vaginal discharge · score 0.18
- Blackfan-Diamond anemia · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- delta-beta-thalassemia · score 0.06
- hemoglobin D disease · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- Alpha-thalassemia · score 0.05
- Beta-thalassemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXH6-F1 | alphafold | PREDICTED | 73.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXH6.
Amino-acid sequence (277 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RAB40A?
The strongest Open Targets associations for RAB40A are vaginal discharge, Blackfan-Diamond anemia, hereditary persistence of fetal hemoglobin-sickle cell disease syndrome, alpha thalassemia-intellectual disability syndrome type 1 and Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16.
How long is the RAB40A protein?
The Homo sapiens RAB40A protein (UniProt Q8WXH6) is 277 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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