Connector enhancer of kinase suppressor of ras 2 (CNKSR2)
Homo sapiens — UniProt Q8WXI2
Data last refreshed: (UniProt release unknown)
Key facts
Connector enhancer of kinase suppressor of ras 2 (CNKSR2) is a protein from Homo sapiens identified by UniProt accession Q8WXI2, 1034 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8WXI2; gene symbol CNKSR2.
- Organism: Homo sapiens.
- Length: 1034 amino acids.
- Top disease associations (Open Targets): X-linked dominant intellectual disability - epilepsy syndrome, cancer and Noonan syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Connector enhancer of kinase suppressor of ras 2 |
|---|---|
| UniProt accession | Q8WXI2 |
| Gene | CNKSR2 |
| Organism | Homo sapiens |
| Length | 1034 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- X-linked dominant intellectual disability - epilepsy syndrome · score 0.75
- cancer · score 0.61
- Noonan syndrome · score 0.53
- Costello syndrome · score 0.50
- hypertrophic cardiomyopathy · score 0.50
- Intellectual disability · score 0.44
- genetic disorder · score 0.41
- cardiofaciocutaneous syndrome · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
- X-linked complex neurodevelopmental disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXI2-F1 | alphafold | PREDICTED | 57.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXI2.
Amino-acid sequence (1034 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNKSR2?
The strongest Open Targets associations for CNKSR2 are X-linked dominant intellectual disability - epilepsy syndrome, cancer, Noonan syndrome, Costello syndrome and hypertrophic cardiomyopathy.
How long is the CNKSR2 protein?
The Homo sapiens CNKSR2 protein (UniProt Q8WXI2) is 1034 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXI2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXI2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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