Ankyrin repeat and SOCS box protein 10 (ASB10)
Homo sapiens — UniProt Q8WXI3
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat and SOCS box protein 10 (ASB10) is a protein from Homo sapiens identified by UniProt accession Q8WXI3, 467 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q8WXI3; gene symbol ASB10.
- Organism: Homo sapiens.
- Length: 467 amino acids.
- Top disease associations (Open Targets): open-angle glaucoma, clear cell renal carcinoma and SAPHO syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat and SOCS box protein 10 |
|---|---|
| UniProt accession | Q8WXI3 |
| Gene | ASB10 |
| Organism | Homo sapiens |
| Length | 467 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- open-angle glaucoma · score 0.76
- clear cell renal carcinoma · score 0.18
- SAPHO syndrome · score 0.10
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- hemoglobin D disease · score 0.06
- dominant beta-thalassemia · score 0.05
- primary familial polycythemia due to EPO receptor mutation · score 0.05
- hemoglobin C-beta-thalassemia syndrome · score 0.05
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.05
- hemoglobin H disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXI3-F1 | alphafold | PREDICTED | 79.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXI3.
Amino-acid sequence (467 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASB10?
The strongest Open Targets associations for ASB10 are open-angle glaucoma, clear cell renal carcinoma, SAPHO syndrome, hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and hemoglobin D disease.
How long is the ASB10 protein?
The Homo sapiens ASB10 protein (UniProt Q8WXI3) is 467 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXI3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXI3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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