Acyl-coenzyme A thioesterase 11 (ACOT11)
Homo sapiens — UniProt Q8WXI4
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-coenzyme A thioesterase 11 (ACOT11) is a protein from Homo sapiens identified by UniProt accession Q8WXI4, 607 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q8WXI4; gene symbol ACOT11.
- Organism: Homo sapiens.
- Length: 607 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-coenzyme A thioesterase 11 |
|---|---|
| UniProt accession | Q8WXI4 |
| Gene | ACOT11 |
| Organism | Homo sapiens |
| Length | 607 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- blood protein measurement · score 0.15
- protein measurement · score 0.13
- intermediate density lipoprotein measurement · score 0.11
- free cholesterol measurement · score 0.11
- cognitive decline measurement · score 0.09
- lung adenocarcinoma · score 0.07
- body height · score 0.06
- neoplasm · score 0.05
- PLIN1-related familial partial lipodystrophy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXI4-F1 | alphafold | PREDICTED | 80.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXI4.
Amino-acid sequence (607 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACOT11?
The strongest Open Targets associations for ACOT11 are neurodegenerative disease, blood protein measurement, protein measurement, intermediate density lipoprotein measurement and free cholesterol measurement.
How long is the ACOT11 protein?
The Homo sapiens ACOT11 protein (UniProt Q8WXI4) is 607 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXI4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXI4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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