C-type lectin domain family 4 member D (CLEC4D)
Homo sapiens — UniProt Q8WXI8
Data last refreshed: (UniProt release unknown)
Key facts
C-type lectin domain family 4 member D (CLEC4D) is a protein from Homo sapiens identified by UniProt accession Q8WXI8, 215 residues long. MolForge cross-references it against 0 known binders and 338 disease associations.
- UniProt accession: Q8WXI8; gene symbol CLEC4D.
- Organism: Homo sapiens.
- Length: 215 amino acids.
- Top disease associations (Open Targets): squamous cell lung carcinoma, head and neck squamous cell carcinoma and colitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | C-type lectin domain family 4 member D |
|---|---|
| UniProt accession | Q8WXI8 |
| Gene | CLEC4D |
| Organism | Homo sapiens |
| Length | 215 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (338)
Diseases linked to this target (Open Targets).
- squamous cell lung carcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.12
- colitis · score 0.08
- neoplasm · score 0.08
- isolated agammaglobulinemia · score 0.08
- common variable immunodeficiency · score 0.08
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.07
- immunodeficiency 62 · score 0.06
- immunodeficiency 18 · score 0.06
- severe combined immunodeficiency due to CARD11 deficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXI8-F1 | alphafold | PREDICTED | 86.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXI8.
Amino-acid sequence (215 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLEC4D?
The strongest Open Targets associations for CLEC4D are squamous cell lung carcinoma, head and neck squamous cell carcinoma, colitis, neoplasm and isolated agammaglobulinemia.
How long is the CLEC4D protein?
The Homo sapiens CLEC4D protein (UniProt Q8WXI8) is 215 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXI8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXI8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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