Transcriptional repressor p66-beta (GATAD2B)
Homo sapiens — UniProt Q8WXI9
Data last refreshed: (UniProt release unknown)
Key facts
Transcriptional repressor p66-beta (GATAD2B) is a protein from Homo sapiens identified by UniProt accession Q8WXI9, 593 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q8WXI9; gene symbol GATAD2B.
- Organism: Homo sapiens.
- Length: 593 amino acids.
- Top disease associations (Open Targets): severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome, Intellectual disability and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcriptional repressor p66-beta |
|---|---|
| UniProt accession | Q8WXI9 |
| Gene | GATAD2B |
| Organism | Homo sapiens |
| Length | 593 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome · score 0.73
- Intellectual disability · score 0.61
- genetic disorder · score 0.53
- neurodegenerative disease · score 0.37
- endometrial cancer · score 0.27
- breast adenocarcinoma · score 0.27
- acute myeloid leukemia · score 0.26
- Parkinson disease · score 0.23
- multiple sclerosis · score 0.23
- lysosomal storage disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXI9-F1 | alphafold | PREDICTED | 58.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXI9.
Amino-acid sequence (593 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GATAD2B?
The strongest Open Targets associations for GATAD2B are severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome, Intellectual disability, genetic disorder, neurodegenerative disease and endometrial cancer.
How long is the GATAD2B protein?
The Homo sapiens GATAD2B protein (UniProt Q8WXI9) is 593 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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