Ankyrin repeat and SOCS box protein 12 (ASB12)
Homo sapiens — UniProt Q8WXK4
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat and SOCS box protein 12 (ASB12) is a protein from Homo sapiens identified by UniProt accession Q8WXK4, 309 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q8WXK4; gene symbol ASB12.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): mean platelet volume, spinal muscular atrophy and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat and SOCS box protein 12 |
|---|---|
| UniProt accession | Q8WXK4 |
| Gene | ASB12 |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.17
- spinal muscular atrophy · score 0.02
- testosterone measurement · score 0.02
- acute quadriplegic myopathy · score 0.01
- IGA glomerulonephritis · score 0.01
- diffuse large B-cell lymphoma · score 0.00
- Azoospermia · score 0.00
- oral squamous cell carcinoma · score 0.00
- osteopathia striata with cranial sclerosis · score 0.00
- type 1 diabetes mellitus · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXK4-F1 | alphafold | PREDICTED | 83.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXK4.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASB12?
The strongest Open Targets associations for ASB12 are mean platelet volume, spinal muscular atrophy, testosterone measurement, acute quadriplegic myopathy and IGA glomerulonephritis.
How long is the ASB12 protein?
The Homo sapiens ASB12 protein (UniProt Q8WXK4) is 309 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXK4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXK4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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