Brain and acute leukemia cytoplasmic protein (BAALC)
Homo sapiens — UniProt Q8WXS3
Data last refreshed: (UniProt release unknown)
Key facts
Brain and acute leukemia cytoplasmic protein (BAALC) is a protein from Homo sapiens identified by UniProt accession Q8WXS3, 145 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8WXS3; gene symbol BAALC.
- Organism: Homo sapiens.
- Length: 145 amino acids.
- Top disease associations (Open Targets): Age-related cataract, acute myeloid leukemia and triple-negative breast cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Brain and acute leukemia cytoplasmic protein |
|---|---|
| UniProt accession | Q8WXS3 |
| Gene | BAALC |
| Organism | Homo sapiens |
| Length | 145 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- Age-related cataract · score 0.15
- acute myeloid leukemia · score 0.08
- triple-negative breast cancer · score 0.08
- esophageal squamous cell carcinoma · score 0.08
- acute lymphoblastic leukemia · score 0.06
- atypical teratoid rhabdoid tumor · score 0.04
- chronic lymphocytic leukemia · score 0.03
- Down syndrome · score 0.02
- neoplasm · score 0.02
- chronic myelogenous leukemia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXS3-F1 | alphafold | PREDICTED | 60.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXS3.
Amino-acid sequence (145 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BAALC?
The strongest Open Targets associations for BAALC are Age-related cataract, acute myeloid leukemia, triple-negative breast cancer, esophageal squamous cell carcinoma and acute lymphoblastic leukemia.
How long is the BAALC protein?
The Homo sapiens BAALC protein (UniProt Q8WXS3) is 145 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXS3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXS3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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