Voltage-dependent calcium channel gamma-like subunit (TMEM37)
Homo sapiens — UniProt Q8WXS4
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-dependent calcium channel gamma-like subunit (TMEM37) is a protein from Homo sapiens identified by UniProt accession Q8WXS4, 190 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q8WXS4; gene symbol TMEM37.
- Organism: Homo sapiens.
- Length: 190 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, monocyte percentage of leukocytes and chronic myelogenous leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-dependent calcium channel gamma-like subunit |
|---|---|
| UniProt accession | Q8WXS4 |
| Gene | TMEM37 |
| Organism | Homo sapiens |
| Length | 190 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.31
- monocyte percentage of leukocytes · score 0.29
- chronic myelogenous leukemia · score 0.07
- infect · score 0.07
- infection · score 0.07
- Crigler-Najjar syndrome type 2 · score 0.06
- schizophrenia · score 0.06
- maple syrup urine disease · score 0.06
- sarcosinemia · score 0.06
- metabolite measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXS4-F1 | alphafold | PREDICTED | 87.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXS4.
Amino-acid sequence (190 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM37?
The strongest Open Targets associations for TMEM37 are high density lipoprotein cholesterol measurement, monocyte percentage of leukocytes, chronic myelogenous leukemia, infect and infection.
How long is the TMEM37 protein?
The Homo sapiens TMEM37 protein (UniProt Q8WXS4) is 190 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXS4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXS4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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