Voltage-dependent calcium channel gamma-8 subunit (CACNG8)
Homo sapiens — UniProt Q8WXS5
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-dependent calcium channel gamma-8 subunit (CACNG8) is a protein from Homo sapiens identified by UniProt accession Q8WXS5, 425 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8WXS5; gene symbol CACNG8.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): cardiovascular disease, generalized anxiety disorder and Polyuria.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-dependent calcium channel gamma-8 subunit |
|---|---|
| UniProt accession | Q8WXS5 |
| Gene | CACNG8 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.46
- generalized anxiety disorder · score 0.39
- Polyuria · score 0.37
- gastrointestinal disease · score 0.37
- Urinary incontinence · score 0.37
- anxiety · score 0.27
- insomnia · score 0.10
- lung adenocarcinoma · score 0.10
- mathematical ability · score 0.07
- cognitive function measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXS5-F1 | alphafold | PREDICTED | 58.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXS5.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CACNG8?
The strongest Open Targets associations for CACNG8 are cardiovascular disease, generalized anxiety disorder, Polyuria, gastrointestinal disease and Urinary incontinence.
How long is the CACNG8 protein?
The Homo sapiens CACNG8 protein (UniProt Q8WXS5) is 425 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXS5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXS5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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