A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14)
Homo sapiens — UniProt Q8WXS8
Data last refreshed: (UniProt release unknown)
Key facts
A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) is a protein from Homo sapiens identified by UniProt accession Q8WXS8, 1223 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q8WXS8; gene symbol ADAMTS14.
- Organism: Homo sapiens.
- Length: 1223 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, heel bone mineral density and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A disintegrin and metalloproteinase with thrombospondin motifs 14 |
|---|---|
| UniProt accession | Q8WXS8 |
| Gene | ADAMTS14 |
| Organism | Homo sapiens |
| Length | 1223 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- heel bone mineral density · score 0.43
- body fat percentage · score 0.39
- appendicular lean mass · score 0.36
- cortical surface area measurement · score 0.30
- optic disc size measurement · score 0.26
- carpal tunnel syndrome · score 0.26
- fat body mass · score 0.25
- breast adenocarcinoma · score 0.25
- brain measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXS8-F1 | alphafold | PREDICTED | 69.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXS8.
Amino-acid sequence (1223 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAMTS14?
The strongest Open Targets associations for ADAMTS14 are neurodegenerative disease, heel bone mineral density, body fat percentage, appendicular lean mass and cortical surface area measurement.
How long is the ADAMTS14 protein?
The Homo sapiens ADAMTS14 protein (UniProt Q8WXS8) is 1223 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXS8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXS8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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