Dynein axonemal assembly factor 4 (DNAAF4)
Homo sapiens — UniProt Q8WXU2
Data last refreshed: (UniProt release unknown)
Key facts
Dynein axonemal assembly factor 4 (DNAAF4) is a protein from Homo sapiens identified by UniProt accession Q8WXU2, 420 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.
- UniProt accession: Q8WXU2; gene symbol DNAAF4.
- Organism: Homo sapiens.
- Length: 420 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, dyslexia and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein axonemal assembly factor 4 |
|---|---|
| UniProt accession | Q8WXU2 |
| Gene | DNAAF4 |
| Organism | Homo sapiens |
| Length | 420 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.69
- dyslexia · score 0.61
- genetic disorder · score 0.19
- appendicular lean mass · score 0.13
- lean body mass · score 0.09
- Heterotaxia · score 0.07
- neoplasm · score 0.07
- body weight · score 0.07
- visceral heterotaxy · score 0.06
- right atrial isomerism · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXU2-F1 | alphafold | PREDICTED | 83.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXU2.
Amino-acid sequence (420 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAAF4?
The strongest Open Targets associations for DNAAF4 are primary ciliary dyskinesia, dyslexia, genetic disorder, appendicular lean mass and lean body mass.
How long is the DNAAF4 protein?
The Homo sapiens DNAAF4 protein (UniProt Q8WXU2) is 420 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXU2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXU2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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