Progesterone-induced-blocking factor 1 (PIBF1)
Homo sapiens — UniProt Q8WXW3
Data last refreshed: (UniProt release unknown)
Key facts
Progesterone-induced-blocking factor 1 (PIBF1) is a protein from Homo sapiens identified by UniProt accession Q8WXW3, 757 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q8WXW3; gene symbol PIBF1.
- Organism: Homo sapiens.
- Length: 757 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Global developmental delay and Ataxia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Progesterone-induced-blocking factor 1 |
|---|---|
| UniProt accession | Q8WXW3 |
| Gene | PIBF1 |
| Organism | Homo sapiens |
| Length | 757 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.74
- Global developmental delay · score 0.46
- Ataxia · score 0.46
- cephalocele · score 0.42
- genetic disorder · score 0.41
- Dandy-Walker syndrome · score 0.32
- creatinine measurement · score 0.27
- gout · score 0.24
- drug use measurement · score 0.21
- ciliopathy · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXW3-F1 | alphafold | PREDICTED | 77.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXW3.
Amino-acid sequence (757 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIBF1?
The strongest Open Targets associations for PIBF1 are Joubert syndrome, Global developmental delay, Ataxia, cephalocele and genetic disorder.
How long is the PIBF1 protein?
The Homo sapiens PIBF1 protein (UniProt Q8WXW3) is 757 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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