Autism susceptibility gene 2 protein (AUTS2)
Homo sapiens — UniProt Q8WXX7
Data last refreshed: (UniProt release unknown)
Key facts
Autism susceptibility gene 2 protein (AUTS2) is a protein from Homo sapiens identified by UniProt accession Q8WXX7, 1259 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q8WXX7; gene symbol AUTS2.
- Organism: Homo sapiens.
- Length: 1259 amino acids.
- Top disease associations (Open Targets): autism spectrum disorder due to AUTS2 deficiency, syndromic intellectual disability and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Autism susceptibility gene 2 protein |
|---|---|
| UniProt accession | Q8WXX7 |
| Gene | AUTS2 |
| Organism | Homo sapiens |
| Length | 1259 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- autism spectrum disorder due to AUTS2 deficiency · score 0.74
- syndromic intellectual disability · score 0.60
- genetic disorder · score 0.51
- body mass index · score 0.45
- multiple congenital anomalies/dysmorphic syndrome-intellectual disability · score 0.44
- type 2 diabetes mellitus · score 0.44
- body fat percentage · score 0.44
- cognitive function measurement · score 0.44
- self reported educational attainment · score 0.42
- sex hormone-binding globulin measurement · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXX7-F1 | alphafold | PREDICTED | 41.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXX7.
Amino-acid sequence (1259 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AUTS2?
The strongest Open Targets associations for AUTS2 are autism spectrum disorder due to AUTS2 deficiency, syndromic intellectual disability, genetic disorder, body mass index and multiple congenital anomalies/dysmorphic syndrome-intellectual disability.
How long is the AUTS2 protein?
The Homo sapiens AUTS2 protein (UniProt Q8WXX7) is 1259 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXX7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXX7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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