VPS10 domain-containing receptor SorCS1 (SORCS1)
Homo sapiens — UniProt Q8WY21
Data last refreshed: (UniProt release unknown)
Key facts
VPS10 domain-containing receptor SorCS1 (SORCS1) is a protein from Homo sapiens identified by UniProt accession Q8WY21, 1168 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q8WY21; gene symbol SORCS1.
- Organism: Homo sapiens.
- Length: 1168 amino acids.
- Top disease associations (Open Targets): metabolite measurement, PHF-tau measurement and early-onset autosomal dominant Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | VPS10 domain-containing receptor SorCS1 |
|---|---|
| UniProt accession | Q8WY21 |
| Gene | SORCS1 |
| Organism | Homo sapiens |
| Length | 1168 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- metabolite measurement · score 0.31
- PHF-tau measurement · score 0.28
- early-onset autosomal dominant Alzheimer disease · score 0.27
- adolescent idiopathic scoliosis · score 0.22
- protein measurement · score 0.18
- physical activity measurement · score 0.15
- optic cup area measurement · score 0.14
- Age-related cataract · score 0.14
- smoking status measurement · score 0.14
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WY21-F1 | alphafold | PREDICTED | 76.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WY21.
Amino-acid sequence (1168 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SORCS1?
The strongest Open Targets associations for SORCS1 are metabolite measurement, PHF-tau measurement, early-onset autosomal dominant Alzheimer disease, adolescent idiopathic scoliosis and protein measurement.
How long is the SORCS1 protein?
The Homo sapiens SORCS1 protein (UniProt Q8WY21) is 1168 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WY21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WY21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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