Protein phosphatase 1E (PPM1E)
Homo sapiens — UniProt Q8WY54
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1E (PPM1E) is a protein from Homo sapiens identified by UniProt accession Q8WY54, 755 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q8WY54; gene symbol PPM1E.
- Organism: Homo sapiens.
- Length: 755 amino acids.
- Top disease associations (Open Targets): mulibrey nanism, systolic blood pressure and testicular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1E |
|---|---|
| UniProt accession | Q8WY54 |
| Gene | PPM1E |
| Organism | Homo sapiens |
| Length | 755 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- mulibrey nanism · score 0.27
- systolic blood pressure · score 0.27
- testicular carcinoma · score 0.15
- Testicular Germ Cell Tumor · score 0.13
- intelligence · score 0.09
- type 2 diabetes mellitus · score 0.08
- drug use measurement · score 0.07
- body height · score 0.06
- cognitive function measurement · score 0.06
- eosinophil count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WY54-F1 | alphafold | PREDICTED | 64.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WY54.
Amino-acid sequence (755 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPM1E?
The strongest Open Targets associations for PPM1E are mulibrey nanism, systolic blood pressure, testicular carcinoma, Testicular Germ Cell Tumor and intelligence.
How long is the PPM1E protein?
The Homo sapiens PPM1E protein (UniProt Q8WY54) is 755 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WY54 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WY54 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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