Peroxynitrite isomerase THAP4 (THAP4)
Homo sapiens — UniProt Q8WY91
Data last refreshed: (UniProt release unknown)
Key facts
Peroxynitrite isomerase THAP4 (THAP4) is a protein from Homo sapiens identified by UniProt accession Q8WY91, 577 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q8WY91; gene symbol THAP4.
- Organism: Homo sapiens.
- Length: 577 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, urate measurement and bone density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peroxynitrite isomerase THAP4 |
|---|---|
| UniProt accession | Q8WY91 |
| Gene | THAP4 |
| Organism | Homo sapiens |
| Length | 577 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- urate measurement · score 0.25
- bone density · score 0.25
- platelet crit · score 0.13
- platelet count · score 0.09
- body weight · score 0.03
- fat body mass · score 0.02
- lean body mass · score 0.02
- acute lymphoblastic leukemia · score 0.01
- mature T-cell and NK-cell non-Hodgkin lymphoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WY91-F1 | alphafold | PREDICTED | 66.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WY91.
Amino-acid sequence (577 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP4?
The strongest Open Targets associations for THAP4 are neurodegenerative disease, urate measurement, bone density, platelet crit and platelet count.
How long is the THAP4 protein?
The Homo sapiens THAP4 protein (UniProt Q8WY91) is 577 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WY91 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WY91 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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