Septin-1 (SEPTIN1)
Homo sapiens — UniProt Q8WYJ6
Data last refreshed: (UniProt release unknown)
Key facts
Septin-1 (SEPTIN1) is a protein from Homo sapiens identified by UniProt accession Q8WYJ6, 372 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8WYJ6; gene symbol SEPTIN1.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): lymphocyte count, mean corpuscular volume and red blood cell density measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Septin-1 |
|---|---|
| UniProt accession | Q8WYJ6 |
| Gene | SEPTIN1 |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.15
- mean corpuscular volume · score 0.11
- red blood cell density measurement · score 0.07
- blood protein measurement · score 0.04
- osteosarcoma · score 0.03
- mean platelet volume · score 0.03
- platelet component distribution width · score 0.03
- hemoglobin measurement · score 0.02
- cardiac troponin I measurement · score 0.02
- oral squamous cell carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WYJ6-F1 | alphafold | PREDICTED | 76.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WYJ6.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEPTIN1?
The strongest Open Targets associations for SEPTIN1 are lymphocyte count, mean corpuscular volume, red blood cell density measurement, blood protein measurement and osteosarcoma.
How long is the SEPTIN1 protein?
The Homo sapiens SEPTIN1 protein (UniProt Q8WYJ6) is 372 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WYJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WYJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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