Acetyl-coenzyme A thioesterase (ACOT12)
Homo sapiens — UniProt Q8WYK0
Data last refreshed: (UniProt release unknown)
Key facts
Acetyl-coenzyme A thioesterase (ACOT12) is a protein from Homo sapiens identified by UniProt accession Q8WYK0, 555 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q8WYK0; gene symbol ACOT12.
- Organism: Homo sapiens.
- Length: 555 amino acids.
- Top disease associations (Open Targets): platelet count, body mass index and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acetyl-coenzyme A thioesterase |
|---|---|
| UniProt accession | Q8WYK0 |
| Gene | ACOT12 |
| Organism | Homo sapiens |
| Length | 555 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- platelet count · score 0.15
- body mass index · score 0.13
- lean body mass · score 0.13
- platelet crit · score 0.12
- bipolar disorder · score 0.12
- fat body mass · score 0.12
- body weight · score 0.10
- body height · score 0.09
- waist circumference · score 0.09
- visceral adipose tissue measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WYK0-F1 | alphafold | PREDICTED | 88.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WYK0.
Amino-acid sequence (555 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACOT12?
The strongest Open Targets associations for ACOT12 are platelet count, body mass index, lean body mass, platelet crit and bipolar disorder.
How long is the ACOT12 protein?
The Homo sapiens ACOT12 protein (UniProt Q8WYK0) is 555 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WYK0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WYK0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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