Ras and Rab interactor 2 (RIN2)
Homo sapiens — UniProt Q8WYP3
Data last refreshed: (UniProt release unknown)
Key facts
Ras and Rab interactor 2 (RIN2) is a protein from Homo sapiens identified by UniProt accession Q8WYP3, 895 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q8WYP3; gene symbol RIN2.
- Organism: Homo sapiens.
- Length: 895 amino acids.
- Top disease associations (Open Targets): RIN2 syndrome, MACS syndrome and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ras and Rab interactor 2 |
|---|---|
| UniProt accession | Q8WYP3 |
| Gene | RIN2 |
| Organism | Homo sapiens |
| Length | 895 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- RIN2 syndrome · score 0.65
- MACS syndrome · score 0.63
- platelet component distribution width · score 0.55
- appendicular lean mass · score 0.42
- mean platelet volume · score 0.35
- lean mass-adjusted fat body mass · score 0.34
- serum albumin measurement · score 0.32
- diffuse plaque measurement · score 0.29
- fat body mass · score 0.19
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WYP3-F1 | alphafold | PREDICTED | 63.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WYP3.
Amino-acid sequence (895 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RIN2?
The strongest Open Targets associations for RIN2 are RIN2 syndrome, MACS syndrome, platelet component distribution width, appendicular lean mass and mean platelet volume.
How long is the RIN2 protein?
The Homo sapiens RIN2 protein (UniProt Q8WYP3) is 895 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WYP3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WYP3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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