Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10)
Homo sapiens — UniProt Q8WYQ3
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10) is a protein from Homo sapiens identified by UniProt accession Q8WYQ3, 142 residues long. MolForge cross-references it against 0 known binders and 187 disease associations.
- UniProt accession: Q8WYQ3; gene symbol CHCHD10.
- Organism: Homo sapiens.
- Length: 142 amino acids.
- Top disease associations (Open Targets): lower motor neuron syndrome with late-adult onset, frontotemporal dementia with motor neuron disease and autosomal dominant mitochondrial myopathy with exercise intolerance.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial |
|---|---|
| UniProt accession | Q8WYQ3 |
| Gene | CHCHD10 |
| Organism | Homo sapiens |
| Length | 142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (187)
Diseases linked to this target (Open Targets).
- lower motor neuron syndrome with late-adult onset · score 0.74
- frontotemporal dementia with motor neuron disease · score 0.72
- autosomal dominant mitochondrial myopathy with exercise intolerance · score 0.70
- Mitochondrial myopathy · score 0.53
- amyotrophic lateral sclerosis · score 0.40
- Amyotrophic lateral sclerosis · score 0.37
- mitochondrial disease · score 0.37
- serum IgG glycosylation measurement · score 0.35
- erythrocyte count · score 0.22
- lymphocyte count · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WYQ3-F1 | alphafold | PREDICTED | 61.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WYQ3.
Amino-acid sequence (142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHCHD10?
The strongest Open Targets associations for CHCHD10 are lower motor neuron syndrome with late-adult onset, frontotemporal dementia with motor neuron disease, autosomal dominant mitochondrial myopathy with exercise intolerance, Mitochondrial myopathy and amyotrophic lateral sclerosis.
How long is the CHCHD10 protein?
The Homo sapiens CHCHD10 protein (UniProt Q8WYQ3) is 142 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WYQ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WYQ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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