Microprocessor complex subunit DGCR8 (DGCR8)
Homo sapiens — UniProt Q8WYQ5
Data last refreshed: (UniProt release unknown)
Key facts
Microprocessor complex subunit DGCR8 (DGCR8) is a protein from Homo sapiens identified by UniProt accession Q8WYQ5, 773 residues long. MolForge cross-references it against 0 known binders and 240 disease associations.
- UniProt accession: Q8WYQ5; gene symbol DGCR8.
- Organism: Homo sapiens.
- Length: 773 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Nephroblastoma and diffuse large B-cell lymphoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Microprocessor complex subunit DGCR8 |
|---|---|
| UniProt accession | Q8WYQ5 |
| Gene | DGCR8 |
| Organism | Homo sapiens |
| Length | 773 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (240)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Nephroblastoma · score 0.37
- diffuse large B-cell lymphoma · score 0.24
- Pleural Mesothelioma · score 0.23
- neoplasm · score 0.20
- body height · score 0.20
- head and neck squamous cell carcinoma · score 0.20
- esophageal squamous cell carcinoma · score 0.19
- serum metabolite measurement · score 0.19
- hepatocellular carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WYQ5-F1 | alphafold | PREDICTED | 63.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WYQ5.
Amino-acid sequence (773 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DGCR8?
The strongest Open Targets associations for DGCR8 are neurodegenerative disease, Nephroblastoma, diffuse large B-cell lymphoma, Pleural Mesothelioma and neoplasm.
How long is the DGCR8 protein?
The Homo sapiens DGCR8 protein (UniProt Q8WYQ5) is 773 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WYQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WYQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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