BTB/POZ domain-containing adapter for CUL3-mediated…

About BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) is a protein from Homo sapiens identified by UniProt accession Q8WZ19, 329 residues long. MolForge cross-references it against 0 known binders and 220 disease associations.

Target properties

Protein name	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
UniProt accession	Q8WZ19
Gene	KCTD13
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (220)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.26
body mass index · score 0.25
heel bone mineral density · score 0.25
body fat percentage · score 0.23
sodium measurement · score 0.20
visceral adipose tissue measurement · score 0.18
C-reactive protein measurement · score 0.18
sex hormone-binding globulin measurement · score 0.13
serum alanine aminotransferase measurement · score 0.13
high density lipoprotein cholesterol measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WZ19-F1	alphafold	PREDICTED	78.73	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WZ19.

Amino-acid sequence (329 residues)

MSAEASGPAA AAAPSLEAPK PSGLEPGPAA YGLKPLTPNS KYVKLNVGGS LHYTTLRTLT GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL RDGSVPLPES TRELGELLGE ARYYLVQGLI EDCQLALQQK RETLSPLCLI PMVTSPREEQ QLLASTSKPV VKLLHNRSNN KYSYTSTSDD NLLKNIELFD KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT KVEFPEARIF EETLNILIYE TPRGPDPALL EATGGAAGAG GAGRGEDEEN REHRVRRIHV RRHITHDERP HGQQIVFKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13)