Transmembrane protein 158 (TMEM158)
Homo sapiens — UniProt Q8WZ71
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 158 (TMEM158) is a protein from Homo sapiens identified by UniProt accession Q8WZ71, 300 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q8WZ71; gene symbol TMEM158.
- Organism: Homo sapiens.
- Length: 300 amino acids.
- Top disease associations (Open Targets): macrophage inflammatory protein 1b measurement, body mass index and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 158 |
|---|---|
| UniProt accession | Q8WZ71 |
| Gene | TMEM158 |
| Organism | Homo sapiens |
| Length | 300 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- macrophage inflammatory protein 1b measurement · score 0.30
- body mass index · score 0.14
- genetic disorder · score 0.12
- schizophrenia · score 0.11
- neoplasm · score 0.09
- body height · score 0.08
- feeling "fed-up" measurement · score 0.07
- glioblastoma multiforme · score 0.07
- gonorrhea · score 0.07
- triple-negative breast cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WZ71-F1 | alphafold | PREDICTED | 56.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WZ71.
Amino-acid sequence (300 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM158?
The strongest Open Targets associations for TMEM158 are macrophage inflammatory protein 1b measurement, body mass index, genetic disorder, schizophrenia and neoplasm.
How long is the TMEM158 protein?
The Homo sapiens TMEM158 protein (UniProt Q8WZ71) is 300 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WZ71 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WZ71 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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