Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1)
Homo sapiens — UniProt Q8WZA1
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) is a protein from Homo sapiens identified by UniProt accession Q8WZA1, 660 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.
- UniProt accession: Q8WZA1; gene symbol POMGNT1.
- Organism: Homo sapiens.
- Length: 660 amino acids.
- Top disease associations (Open Targets): muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3, muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B3 and autosomal recessive limb-girdle muscular dystrophy type 2O.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 |
|---|---|
| UniProt accession | Q8WZA1 |
| Gene | POMGNT1 |
| Organism | Homo sapiens |
| Length | 660 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (167)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3 · score 0.83
- muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B3 · score 0.81
- autosomal recessive limb-girdle muscular dystrophy type 2O · score 0.79
- retinitis pigmentosa 76 · score 0.76
- muscular dystrophy-dystroglycanopathy, type A · score 0.67
- limb-girdle muscular dystrophy · score 0.67
- muscle-eye-brain disease · score 0.65
- autosomal recessive limb-girdle muscular dystrophy · score 0.60
- Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies · score 0.57
- muscular dystrophy-dystroglycanopathy · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WZA1-F1 | alphafold | PREDICTED | 89.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WZA1.
Amino-acid sequence (660 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POMGNT1?
The strongest Open Targets associations for POMGNT1 are muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3, muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B3, autosomal recessive limb-girdle muscular dystrophy type 2O, retinitis pigmentosa 76 and muscular dystrophy-dystroglycanopathy, type A.
How long is the POMGNT1 protein?
The Homo sapiens POMGNT1 protein (UniProt Q8WZA1) is 660 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WZA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WZA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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