Rap guanine nucleotide exchange factor 4 (RAPGEF4)
Homo sapiens — UniProt Q8WZA2
Data last refreshed: (UniProt release unknown)
Key facts
Rap guanine nucleotide exchange factor 4 (RAPGEF4) is a protein from Homo sapiens identified by UniProt accession Q8WZA2, 1011 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.
- UniProt accession: Q8WZA2; gene symbol RAPGEF4.
- Organism: Homo sapiens.
- Length: 1011 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, mathematical ability and glucose measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rap guanine nucleotide exchange factor 4 |
|---|---|
| UniProt accession | Q8WZA2 |
| Gene | RAPGEF4 |
| Organism | Homo sapiens |
| Length | 1011 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (295)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.41
- mathematical ability · score 0.41
- glucose measurement · score 0.35
- intelligence · score 0.31
- schizophrenia · score 0.31
- antisocial behaviour measurement · score 0.25
- substance abuse · score 0.25
- attention deficit hyperactivity disorder · score 0.25
- breast adenocarcinoma · score 0.22
- gut microbiome measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WZA2-F1 | alphafold | PREDICTED | 86.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WZA2.
Amino-acid sequence (1011 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RAPGEF4?
The strongest Open Targets associations for RAPGEF4 are self reported educational attainment, mathematical ability, glucose measurement, intelligence and schizophrenia.
How long is the RAPGEF4 protein?
The Homo sapiens RAPGEF4 protein (UniProt Q8WZA2) is 1011 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WZA2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WZA2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.