Immunity-related GTPase family Q protein (IRGQ)
Homo sapiens — UniProt Q8WZA9
Data last refreshed: (UniProt release unknown)
Key facts
Immunity-related GTPase family Q protein (IRGQ) is a protein from Homo sapiens identified by UniProt accession Q8WZA9, 623 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q8WZA9; gene symbol IRGQ.
- Organism: Homo sapiens.
- Length: 623 amino acids.
- Top disease associations (Open Targets): appendicular lean mass, prostate carcinoma and Familial prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Immunity-related GTPase family Q protein |
|---|---|
| UniProt accession | Q8WZA9 |
| Gene | IRGQ |
| Organism | Homo sapiens |
| Length | 623 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.20
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- body height · score 0.05
- hypertriglyceridemia 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- low density lipoprotein cholesterol measurement · score 0.05
- Crigler-Najjar syndrome type 2 · score 0.04
- Combined hyperlipidemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WZA9-F1 | alphafold | PREDICTED | 66.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WZA9.
Amino-acid sequence (623 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IRGQ?
The strongest Open Targets associations for IRGQ are appendicular lean mass, prostate carcinoma, Familial prostate cancer, prostate cancer and body height.
How long is the IRGQ protein?
The Homo sapiens IRGQ protein (UniProt Q8WZA9) is 623 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WZA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WZA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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