Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)
Homo sapiens — UniProt Q92484
Data last refreshed: (UniProt release unknown)
Key facts
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) is a protein from Homo sapiens identified by UniProt accession Q92484, 453 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q92484; gene symbol SMPDL3A.
- Organism: Homo sapiens.
- Length: 453 amino acids.
- Top disease associations (Open Targets): blood protein measurement, acid sphingomyelinase-like phosphodiesterase 3a measurement and cerebrospinal fluid biomarker measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cyclic GMP-AMP phosphodiesterase SMPDL3A |
|---|---|
| UniProt accession | Q92484 |
| Gene | SMPDL3A |
| Organism | Homo sapiens |
| Length | 453 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.45
- acid sphingomyelinase-like phosphodiesterase 3a measurement · score 0.33
- cerebrospinal fluid biomarker measurement · score 0.32
- hepatocellular carcinoma · score 0.07
- drug use measurement · score 0.07
- neoplasm · score 0.07
- protein measurement · score 0.05
- Romano-Ward syndrome · score 0.04
- Familial short QT syndrome · score 0.04
- Familial progressive cardiac conduction defect · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q92484-F1 | alphafold | PREDICTED | 93.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q92484.
Amino-acid sequence (453 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMPDL3A?
The strongest Open Targets associations for SMPDL3A are blood protein measurement, acid sphingomyelinase-like phosphodiesterase 3a measurement, cerebrospinal fluid biomarker measurement, hepatocellular carcinoma and drug use measurement.
How long is the SMPDL3A protein?
The Homo sapiens SMPDL3A protein (UniProt Q92484) is 453 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q92484 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q92484 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.