Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)

About Cyclic GMP-AMP phosphodiesterase SMPDL3A

Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) is a protein from Homo sapiens identified by UniProt accession Q92484, 453 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Cyclic GMP-AMP phosphodiesterase SMPDL3A
UniProt accession	Q92484
Gene	SMPDL3A
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.45
acid sphingomyelinase-like phosphodiesterase 3a measurement · score 0.33
cerebrospinal fluid biomarker measurement · score 0.32
hepatocellular carcinoma · score 0.07
drug use measurement · score 0.07
neoplasm · score 0.07
protein measurement · score 0.05
Romano-Ward syndrome · score 0.04
Familial short QT syndrome · score 0.04
Familial progressive cardiac conduction defect · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92484-F1	alphafold	PREDICTED	93.42	—

Amino-acid sequence (453 residues)

MALVRALVCC LLTAWHCRSG LGLPVAPAGG RNPPPAIGQF WHVTDLHLDP TYHITDDHTK VCASSKGANA SNPGPFGDVL CDSPYQLILS AFDFIKNSGQ EASFMIWTGD SPPHVPVPEL STDTVINVIT NMTTTIQSLF PNLQVFPALG NHDYWPQDQL PVVTSKVYNA VANLWKPWLD EEAISTLRKG GFYSQKVTTN PNLRIISLNT NLYYGPNIMT LNKTDPANQF EWLESTLNNS QQNKEKVYII AHVPVGYLPS SQNITAMREY YNEKLIDIFQ KYSDVIAGQF YGHTHRDSIM VLSDKKGSPV NSLFVAPAVT PVKSVLEKQT NNPGIRLFQY DPRDYKLLDM LQYYLNLTEA NLKGESIWKL EYILTQTYDI EDLQPESLYG LAKQFTILDS KQFIKYYNYF FVSYDSSVTC DKTCKAFQIC AIMNLDNISY ADCLKQLYIK HNY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards