Growth hormone secretagogue receptor type 1 (GHSR)

About Growth hormone secretagogue receptor type 1

Growth hormone secretagogue receptor type 1 (GHSR) is a protein from Homo sapiens identified by UniProt accession Q92847, 366 residues long. MolForge cross-references it against 0 known binders and 339 disease associations.

Target properties

Protein name	Growth hormone secretagogue receptor type 1
UniProt accession	Q92847
Gene	GHSR
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (339)

Diseases linked to this target (Open Targets).

short stature due to GHSR deficiency · score 0.70
body height · score 0.57
lean body mass · score 0.53
IGF-1 measurement · score 0.50
forced expiratory volume · score 0.44
refractive error measurement · score 0.44
appendicular lean mass · score 0.40
whole body water mass · score 0.40
leukocyte count · score 0.39
body weight · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92847-F1	alphafold	PREDICTED	81.60	—

Amino-acid sequence (366 residues)

MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT ESSINT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards