Anamorelin

Drug profile

Key facts

Anamorelin is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2021. DrugCentral lists 1 molecular target, including GHSR. Recorded indications include Cancer cachexia.

• Molecular targets: GHSR (1 listed in DrugCentral).
• Indications: Cancer cachexia.
• Molecular formula: C31H42N6O3; molecular weight 546.72 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Cancer cachexia

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Growth hormone secretagogue receptor type 1	GHSR	agonist	IC50 8.14

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2021-01-22	PMDA	—	ONO PHARMACEUTICAL Co., Ltd

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Malignant neoplasm progression	104.3
Non-small cell lung cancer	59.7
Interstitial lung disease	47.0

Chemical structure

• Molecular formula: C₃₁H₄₂N₆O₃
• Molecular weight: 546.72 g/mol
• CAS number: 861998-00-7
• InChIKey: VQPFSIRUEPQQPP-MXBOTTGLSA-N
• PubChem CID: 9828911

CC(C)(C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N3CCC[C@](C3)(CC4=CC=CC=C4)C(=O)N(C)N(C)C)N

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Anamorelin used for?

DrugCentral lists the following indications for Anamorelin: Cancer cachexia.

How does Anamorelin work?

Its molecular targets in DrugCentral include GHSR (agonist).

When was Anamorelin first approved?

Anamorelin was first approved by the PMDA in 2021.

What is the chemical formula of Anamorelin?

Anamorelin has the molecular formula C31H42N6O3 and a molecular weight of 546.72 g/mol.

Sources

• DrugCentral drug card 5487 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2103794 — compound record and bioactivity
• PubChem CID 9828911 — chemical identifiers
• DrugBank DB06645 — drug record
• FDA UNII DD5RBA1NKF — substance identity
• UniProt Q92847 (GHSR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.