Macimorelin

Growth Hormone Secretagogue Receptor Agonist — VARIOUS

Key facts

Macimorelin is an ofm drug in the Growth Hormone Secretagogue Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 2017. Its mechanism of action is classified as Growth Hormone Secretagogue Receptor Agonists. DrugCentral lists 1 molecular target, including GHSR.

• Approval status: ofm (first approved 2017 by the FDA).
• Drug class: Growth Hormone Secretagogue Receptor Agonist.
• Mechanism of action: Growth Hormone Secretagogue Receptor Agonists.
• Molecular targets: GHSR (1 listed in DrugCentral).
• ATC code: V04CD06 (Tests for pituitary function).
• Molecular formula: C26H30N6O3; molecular weight 474.56 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Diagnosis (1)

• Adult growth hormone deficiency

Mechanism & targets

• Mechanism of action (MoA): Growth Hormone Secretagogue Receptor Agonists
• Established pharmacologic class: Growth Hormone Secretagogue Receptor Agonist

Molecular targets (1)

Target	Gene	Action	Activity
Growth hormone secretagogue receptor type 1	GHSR	agonist	IC50 7.81

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2019-01-11	EMA	—	AETERNA ZENTARIS GMBH
2017-12-20	FDA	—	AETERNA ZENTARIS GMBH	Yes

ATC classification

ATC code	Therapeutic hierarchy
V04CD06	VARIOUS › DIAGNOSTIC AGENTS › OTHER DIAGNOSTIC AGENTS › Tests for pituitary function

Chemical structure

• Molecular formula: C₂₆H₃₀N₆O₃
• Molecular weight: 474.56 g/mol
• CAS number: —
• InChIKey: VPBQKRKRYYPMOF-DHIUTWEWSA-N
• PubChem CID: 9804938

CC(C)(N)C(=O)N[C@H](CC1=CC2=C(N1)C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)NC=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Macimorelin work?

Macimorelin is classified as Growth Hormone Secretagogue Receptor Agonists; its molecular targets in DrugCentral include GHSR (agonist).

When was Macimorelin first approved?

Macimorelin was first approved by the FDA in 2017.

What drug class does Macimorelin belong to?

Macimorelin is in the Growth Hormone Secretagogue Receptor Agonist class.

What is the chemical formula of Macimorelin?

Macimorelin has the molecular formula C26H30N6O3 and a molecular weight of 474.56 g/mol.

Sources

• DrugCentral drug card 5271 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2364617 — compound record and bioactivity
• PubChem CID 9804938 — chemical identifiers
• DrugBank DB13074 — drug record
• FDA UNII 8680B21W73 — substance identity
• DailyMed: FDA labels for Macimorelin — current prescribing information (label search)
• UniProt Q92847 (GHSR) — target protein

How this page is built: methodology · editorial policy & corrections.