Transcription factor IIIB 90 kDa subunit (BRF1)
Homo sapiens — UniProt Q92994
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor IIIB 90 kDa subunit (BRF1) is a protein from Homo sapiens identified by UniProt accession Q92994, 677 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q92994; gene symbol BRF1.
- Organism: Homo sapiens.
- Length: 677 amino acids.
- Top disease associations (Open Targets): Cerebellar-facial-dental syndrome, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor IIIB 90 kDa subunit |
|---|---|
| UniProt accession | Q92994 |
| Gene | BRF1 |
| Organism | Homo sapiens |
| Length | 677 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- Cerebellar-facial-dental syndrome · score 0.77
- genetic disorder · score 0.49
- neurodegenerative disease · score 0.49
- Intellectual disability · score 0.40
- Abnormality of the inner ear · score 0.34
- congenital heart disease · score 0.34
- Abnormal heart morphology · score 0.34
- sensorineural hearing loss · score 0.34
- Sensorineural hearing impairment · score 0.34
- Intellectual disability, moderate · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q92994-F1 | alphafold | PREDICTED | 69.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q92994.
Amino-acid sequence (677 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRF1?
The strongest Open Targets associations for BRF1 are Cerebellar-facial-dental syndrome, genetic disorder, neurodegenerative disease, Intellectual disability and Abnormality of the inner ear.
How long is the BRF1 protein?
The Homo sapiens BRF1 protein (UniProt Q92994) is 677 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q92994 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q92994 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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