Protein naked cuticle homolog 1 (NKD1)
Homo sapiens — UniProt Q969G9
Data last refreshed: (UniProt release unknown)
Key facts
Protein naked cuticle homolog 1 (NKD1) is a protein from Homo sapiens identified by UniProt accession Q969G9, 470 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.
- UniProt accession: Q969G9; gene symbol NKD1.
- Organism: Homo sapiens.
- Length: 470 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Crohn's disease and inflammatory bowel disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein naked cuticle homolog 1 |
|---|---|
| UniProt accession | Q969G9 |
| Gene | NKD1 |
| Organism | Homo sapiens |
| Length | 470 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (153)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- Crohn's disease · score 0.41
- inflammatory bowel disease · score 0.35
- systolic blood pressure · score 0.34
- drug use measurement · score 0.32
- lysosomal storage disease · score 0.29
- hepatocellular carcinoma · score 0.10
- colon carcinoma · score 0.09
- azoospermia · score 0.09
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q969G9-F1 | alphafold | PREDICTED | 54.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q969G9.
Amino-acid sequence (470 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NKD1?
The strongest Open Targets associations for NKD1 are neurodegenerative disease, Crohn's disease, inflammatory bowel disease, systolic blood pressure and drug use measurement.
How long is the NKD1 protein?
The Homo sapiens NKD1 protein (UniProt Q969G9) is 470 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q969G9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q969G9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.