E3 ubiquitin-protein ligase TRIM63 (TRIM63)
Homo sapiens — UniProt Q969Q1
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRIM63 (TRIM63) is a protein from Homo sapiens identified by UniProt accession Q969Q1, 353 residues long. MolForge cross-references it against 0 known binders and 414 disease associations.
- UniProt accession: Q969Q1; gene symbol TRIM63.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Top disease associations (Open Targets): hypertrophic cardiomyopathy, genetic disorder and restrictive cardiomyopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM63 |
|---|---|
| UniProt accession | Q969Q1 |
| Gene | TRIM63 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (414)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.58
- genetic disorder · score 0.47
- restrictive cardiomyopathy · score 0.37
- idiopathic cardiomyopathy · score 0.34
- electrocardiography · score 0.29
- appendicular lean mass · score 0.21
- QRS complex · score 0.20
- QRS amplitude · score 0.20
- clear cell renal carcinoma · score 0.19
- type 2 diabetes mellitus · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q969Q1-F1 | alphafold | PREDICTED | 82.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q969Q1.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM63?
The strongest Open Targets associations for TRIM63 are hypertrophic cardiomyopathy, genetic disorder, restrictive cardiomyopathy, idiopathic cardiomyopathy and electrocardiography.
How long is the TRIM63 protein?
The Homo sapiens TRIM63 protein (UniProt Q969Q1) is 353 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q969Q1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q969Q1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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