Transmembrane protein 106A (TMEM106A)
Homo sapiens — UniProt Q96A25
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 106A (TMEM106A) is a protein from Homo sapiens identified by UniProt accession Q96A25, 262 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q96A25; gene symbol TMEM106A.
- Organism: Homo sapiens.
- Length: 262 amino acids.
- Top disease associations (Open Targets): neoplasm, hepatocellular carcinoma and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 106A |
|---|---|
| UniProt accession | Q96A25 |
| Gene | TMEM106A |
| Organism | Homo sapiens |
| Length | 262 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.09
- hepatocellular carcinoma · score 0.07
- leukocyte count · score 0.07
- neutrophil percentage of leukocytes · score 0.06
- granulocyte count · score 0.06
- heel bone mineral density · score 0.06
- myeloid white cell count · score 0.05
- age at menopause · score 0.05
- neutrophil count · score 0.05
- gonorrhea · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96A25-F1 | alphafold | PREDICTED | 75.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A25.
Amino-acid sequence (262 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM106A?
The strongest Open Targets associations for TMEM106A are neoplasm, hepatocellular carcinoma, leukocyte count, neutrophil percentage of leukocytes and granulocyte count.
How long is the TMEM106A protein?
The Homo sapiens TMEM106A protein (UniProt Q96A25) is 262 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96A25 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96A25 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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