E3 ubiquitin-protein ligase RNF166 (RNF166)
Homo sapiens — UniProt Q96A37
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF166 (RNF166) is a protein from Homo sapiens identified by UniProt accession Q96A37, 237 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q96A37; gene symbol RNF166.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): monocyte count, sunburn and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF166 |
|---|---|
| UniProt accession | Q96A37 |
| Gene | RNF166 |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.20
- sunburn · score 0.17
- lean body mass · score 0.10
- reticulocyte count · score 0.09
- platelet crit · score 0.07
- HbA1c measurement · score 0.07
- Varicose veins · score 0.07
- heel bone mineral density · score 0.07
- body height · score 0.07
- Red cell distribution width · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96A37-F1 | alphafold | PREDICTED | 84.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A37.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF166?
The strongest Open Targets associations for RNF166 are monocyte count, sunburn, lean body mass, reticulocyte count and platelet crit.
How long is the RNF166 protein?
The Homo sapiens RNF166 protein (UniProt Q96A37) is 237 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96A37 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96A37 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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