SPRY domain-containing SOCS box protein 4 (SPSB4)
Homo sapiens — UniProt Q96A44
Data last refreshed: (UniProt release unknown)
Key facts
SPRY domain-containing SOCS box protein 4 (SPSB4) is a protein from Homo sapiens identified by UniProt accession Q96A44, 273 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q96A44; gene symbol SPSB4.
- Organism: Homo sapiens.
- Length: 273 amino acids.
- Top disease associations (Open Targets): optic cup area measurement, pancreatic adenocarcinoma and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SPRY domain-containing SOCS box protein 4 |
|---|---|
| UniProt accession | Q96A44 |
| Gene | SPSB4 |
| Organism | Homo sapiens |
| Length | 273 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- optic cup area measurement · score 0.26
- pancreatic adenocarcinoma · score 0.18
- leukocyte count · score 0.03
- neutrophil percentage of leukocytes · score 0.03
- neutrophil count · score 0.02
- Ataxia-telangiectasia · score 0.02
- uterine leiomyosarcoma · score 0.02
- hepatocellular carcinoma · score 0.01
- cancer · score 0.01
- Autism · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96A44-F1 | alphafold | PREDICTED | 89.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A44.
Amino-acid sequence (273 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPSB4?
The strongest Open Targets associations for SPSB4 are optic cup area measurement, pancreatic adenocarcinoma, leukocyte count, neutrophil percentage of leukocytes and neutrophil count.
How long is the SPSB4 protein?
The Homo sapiens SPSB4 protein (UniProt Q96A44) is 273 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96A44 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96A44 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.