Insulin gene enhancer protein ISL-2 (ISL2)

About Insulin gene enhancer protein ISL-2

Insulin gene enhancer protein ISL-2 (ISL2) is a protein from Homo sapiens identified by UniProt accession Q96A47, 359 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Insulin gene enhancer protein ISL-2
UniProt accession	Q96A47
Gene	ISL2
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
cortical surface area measurement · score 0.16
peak expiratory flow · score 0.15
smoking cessation · score 0.15
glomerular filtration rate · score 0.14
Cleft palate · score 0.13
urate measurement · score 0.11
hematocrit · score 0.09
alcohol consumption measurement · score 0.08
central nervous system cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96A47-F1	alphafold	PREDICTED	69.03	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A47.

Amino-acid sequence (359 residues)

MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA ACLKCAECSQ YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCQVGFSSSD LVMRARDSVY HIECFRCSVC SRQLLPGDEF SLREHELLCR ADHGLLLERA AAGSPRSPGP LPGARGLHLP DAGSGRQPAL RPHVHKQTEK TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKKS ILMKQLQQQQ HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN SMVPSPVET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards