E3 ubiquitin-protein ligase TRIM52 (TRIM52)
Homo sapiens — UniProt Q96A61
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRIM52 (TRIM52) is a protein from Homo sapiens identified by UniProt accession Q96A61, 297 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q96A61; gene symbol TRIM52.
- Organism: Homo sapiens.
- Length: 297 amino acids.
- Top disease associations (Open Targets): hepatocellular carcinoma, neoplasm and insulin like growth factor measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM52 |
|---|---|
| UniProt accession | Q96A61 |
| Gene | TRIM52 |
| Organism | Homo sapiens |
| Length | 297 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.07
- insulin like growth factor measurement · score 0.04
- cancer · score 0.04
- alkaline phosphatase measurement · score 0.04
- hair colour measurement · score 0.04
- glioblastoma · score 0.04
- inflammatory bowel disease · score 0.03
- diffuse large B-cell lymphoma · score 0.03
- calf circumference measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96A61-F1 | alphafold | PREDICTED | 67.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A61.
Amino-acid sequence (297 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM52?
The strongest Open Targets associations for TRIM52 are hepatocellular carcinoma, neoplasm, insulin like growth factor measurement, cancer and alkaline phosphatase measurement.
How long is the TRIM52 protein?
The Homo sapiens TRIM52 protein (UniProt Q96A61) is 297 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96A61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96A61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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