Tuberoinfundibular peptide of 39 residues (PTH2)
Homo sapiens — UniProt Q96A98
Data last refreshed: (UniProt release unknown)
Key facts
Tuberoinfundibular peptide of 39 residues (PTH2) is a protein from Homo sapiens identified by UniProt accession Q96A98, 100 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.
- UniProt accession: Q96A98; gene symbol PTH2.
- Organism: Homo sapiens.
- Length: 100 amino acids.
- Top disease associations (Open Targets): azoospermia, Testicular regression syndrome and isolated congenital hypogonadotropic hypogonadism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tuberoinfundibular peptide of 39 residues |
|---|---|
| UniProt accession | Q96A98 |
| Gene | PTH2 |
| Organism | Homo sapiens |
| Length | 100 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (130)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.08
- Testicular regression syndrome · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.07
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- 46,XX testicular disorder of sex development · score 0.06
- primary ovarian insufficiency · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.06
- 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency · score 0.06
- 46,XX gonadal dysgenesis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96A98-F1 | alphafold | PREDICTED | 72.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A98.
Amino-acid sequence (100 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTH2?
The strongest Open Targets associations for PTH2 are azoospermia, Testicular regression syndrome, isolated congenital hypogonadotropic hypogonadism, partial chromosome Y deletion and male infertility with teratozoospermia due to single gene mutation.
How long is the PTH2 protein?
The Homo sapiens PTH2 protein (UniProt Q96A98) is 100 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96A98 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96A98 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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