Pentraxin-4 (PTX4)
Homo sapiens — UniProt Q96A99
Data last refreshed: (UniProt release unknown)
Key facts
Pentraxin-4 (PTX4) is a protein from Homo sapiens identified by UniProt accession Q96A99, 478 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q96A99; gene symbol PTX4.
- Organism: Homo sapiens.
- Length: 478 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, rheumatoid arthritis and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pentraxin-4 |
|---|---|
| UniProt accession | Q96A99 |
| Gene | PTX4 |
| Organism | Homo sapiens |
| Length | 478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- rheumatoid arthritis · score 0.17
- heel bone mineral density · score 0.11
- platelet count · score 0.10
- sitting height measurement · score 0.09
- body height · score 0.04
- femoral neck bone mineral density · score 0.03
- otosclerosis · score 0.03
- neoplasm · score 0.01
- infect · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96A99-F1 | alphafold | PREDICTED | 78.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96A99.
Amino-acid sequence (478 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTX4?
The strongest Open Targets associations for PTX4 are neurodegenerative disease, rheumatoid arthritis, heel bone mineral density, platelet count and sitting height measurement.
How long is the PTX4 protein?
The Homo sapiens PTX4 protein (UniProt Q96A99) is 478 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96A99 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96A99 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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