DNA dC->dU-editing enzyme APOBEC-3D (APOBEC3D)
Homo sapiens — UniProt Q96AK3
Data last refreshed: (UniProt release unknown)
Key facts
DNA dC->dU-editing enzyme APOBEC-3D (APOBEC3D) is a protein from Homo sapiens identified by UniProt accession Q96AK3, 386 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q96AK3; gene symbol APOBEC3D.
- Organism: Homo sapiens.
- Length: 386 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hemoglobin A1 measurement and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA dC->dU-editing enzyme APOBEC-3D |
|---|---|
| UniProt accession | Q96AK3 |
| Gene | APOBEC3D |
| Organism | Homo sapiens |
| Length | 386 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- hemoglobin A1 measurement · score 0.17
- urate measurement · score 0.09
- immune deficiency, familial variable · score 0.08
- immunodeficiency 35 · score 0.07
- Chronic mucocutaneous candidosis · score 0.07
- hyper-IgM syndrome type 2 · score 0.07
- isolated agammaglobulinemia · score 0.07
- immunodeficiency, common variable, 4 · score 0.06
- hyper-IgM syndrome type 3 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96AK3-F1 | alphafold | PREDICTED | 87.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96AK3.
Amino-acid sequence (386 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APOBEC3D?
The strongest Open Targets associations for APOBEC3D are neurodegenerative disease, hemoglobin A1 measurement, urate measurement, immune deficiency, familial variable and immunodeficiency 35.
How long is the APOBEC3D protein?
The Homo sapiens APOBEC3D protein (UniProt Q96AK3) is 386 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96AK3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96AK3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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