Transmembrane protein 125 (TMEM125)
Homo sapiens — UniProt Q96AQ2
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 125 (TMEM125) is a protein from Homo sapiens identified by UniProt accession Q96AQ2, 219 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q96AQ2; gene symbol TMEM125.
- Organism: Homo sapiens.
- Length: 219 amino acids.
- Top disease associations (Open Targets): blood phosphate measurement, creatinine measurement and cystatin C measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 125 |
|---|---|
| UniProt accession | Q96AQ2 |
| Gene | TMEM125 |
| Organism | Homo sapiens |
| Length | 219 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- blood phosphate measurement · score 0.13
- creatinine measurement · score 0.12
- cystatin C measurement · score 0.12
- kidney injury molecule 1 measurement · score 0.10
- non-small cell lung carcinoma · score 0.02
- glioblastoma multiforme · score 0.02
- hepatocellular carcinoma · score 0.01
- Crohn's disease · score 0.01
- Kidney Oncocytoma · score 0.01
- lung adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96AQ2-F1 | alphafold | PREDICTED | 67.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96AQ2.
Amino-acid sequence (219 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM125?
The strongest Open Targets associations for TMEM125 are blood phosphate measurement, creatinine measurement, cystatin C measurement, kidney injury molecule 1 measurement and non-small cell lung carcinoma.
How long is the TMEM125 protein?
The Homo sapiens TMEM125 protein (UniProt Q96AQ2) is 219 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96AQ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96AQ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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