Interferon-stimulated gene 20 kDa protein (ISG20)
Homo sapiens — UniProt Q96AZ6
Data last refreshed: (UniProt release unknown)
Key facts
Interferon-stimulated gene 20 kDa protein (ISG20) is a protein from Homo sapiens identified by UniProt accession Q96AZ6, 181 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.
- UniProt accession: Q96AZ6; gene symbol ISG20.
- Organism: Homo sapiens.
- Length: 181 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interferon-stimulated gene 20 kDa protein |
|---|---|
| UniProt accession | Q96AZ6 |
| Gene | ISG20 |
| Organism | Homo sapiens |
| Length | 181 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (119)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- neuroinflammatory disorder · score 0.37
- mean corpuscular hemoglobin · score 0.36
- mean corpuscular volume · score 0.35
- mean corpuscular hemoglobin concentration · score 0.33
- sitting height measurement · score 0.22
- age-related hearing impairment · score 0.18
- Dupuytren Contracture · score 0.14
- Fasciitis · score 0.14
- Palmar Fibromatosis · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96AZ6-F1 | alphafold | PREDICTED | 95.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96AZ6.
Amino-acid sequence (181 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ISG20?
The strongest Open Targets associations for ISG20 are neurodegenerative disease, neuroinflammatory disorder, mean corpuscular hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin concentration.
How long is the ISG20 protein?
The Homo sapiens ISG20 protein (UniProt Q96AZ6) is 181 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96AZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96AZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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